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Chronic users of Ecstasy perform more poorly than nonusers on certain types of cognitive or memory tasks. In high doses, Ecstasy can interfere with the body's ability to regulate temperature. This can lead to a sharp increase in body temperature (hyperthermia), resulting in liver, kidney and cardiovascular system failure.

Users of Ecstasy face many of the same risks as users of other stimulants such as cocaine and amphetamines. These include increases in heart rate and blood pressure and other symptoms such as muscle tension, involuntary teeth clenching, nausea, blurred vision, faintness, chills or sweating. Psychological effects can include confusion, depression, sleep problems, drug craving and severe anxiety. These can occur days or weeks after taking Ecstasy. Note, however, that the "pure" ecstasy user is a very rare entity. The overwhelming majority of persons who take ecstasy also use other drugs, and some of these drugs are clearly identified with a risk of mental health consequences as well.

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